First Header Logo Second Header Logo

Search Result Details

Back to Search Results
This page shows the details of why an item matched the keywords from your search.
Search Results
Gmeiner, William
One or more keywords matched the following items that are connected to Gmeiner, William
Item TypeName
Academic Article Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
Academic Article Intramolecular binding of a proximal PPII helix to an SH3 domain in the fusion protein SH3Hck : PPIIhGAP.
Academic Article The structure and dynamics of the U4/U6 snRNP: implications for pre-mRNA splicing and use as a model system to investigate the RNA-mediated effects of (5F)Ura.
Academic Article Effect of 5-FU substitution and mutation on Sm protein binding to human U4 snRNA.
Academic Article Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts.
Academic Article Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
Academic Article Line shape analyses for water 17O NMR quintet observed in a bacteriophage Pf1 solution at different temperatures.
Academic Article NMR structure of the thrombin-binding DNA aptamer stabilized by Sr2+.
Academic Article Novel chemical strategies for thymidylate synthase inhibition.
Academic Article Unfolding of G-quadruplexes: energetic, and ion and water contributions of G-quartet stacking.
Academic Article Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
Academic Article Tissue-dependent and -independent gene expression changes in metastatic colon cancer.
Academic Article Increased heating efficiency and selective thermal ablation of malignant tissue with DNA-encased multiwalled carbon nanotubes.
Academic Article Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Academic Article Zn2+ selectively stabilizes FdU-substituted DNA through a unique major groove binding motif.
Academic Article Cooperative stabilization of Zn(2+):DNA complexes through netropsin binding in the minor groove of FdU-substituted DNA.
Academic Article Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.
Academic Article Structure and conformation in solution of the parallel-stranded hybrid alpha-d(CGCAATTCGC).beta-d(GCGTTAAGCG) by high-resolution 2D NMR.
Academic Article Separation of NOEs from degenerate amide protons in 13C/15N-labeled proteins using a 3D 13C'-edited NOESY-H(N)CO experiment.
Academic Article A linear 23-residue peptide reveals a propensity to form an unusual native-like conformation.
Academic Article Solution structures of 5-fluorouracil-substituted DNA and RNA decamer duplexes.
Academic Article The 5' stem-loop from human U4 snRNA adopts a novel conformation stabilized by G-C and G-U base pairs.
Academic Article Three-dimensional structure of the Hck SH2 domain in solution.
Academic Article Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.
Academic Article NMR spectroscopy as a tool to investigate the structural basis of anticancer drugs.
Academic Article Solution structure of the human Hck SH3 domain and identification of its ligand binding site.
Academic Article Effect of cytarabine on the NMR structure of a model okazaki fragment from the SV40 genome.
Academic Article Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins.
Academic Article Shape-selective binding of geometrically-constrained bis-distamycins to a DNA duplex and a model Okazaki fragment of identical sequence.
Academic Article Structure of the Sm binding site from human U4 snRNA derived from a 3 ns PME molecular dynamics simulation.
Academic Article Molecular dynamics simulation of the human U2B" protein complex with U2 snRNA hairpin IV in aqueous solution.
Academic Article NMR structure of a gemcitabine-substituted model Okazaki fragment.
Academic Article Implications of SH3 domain structure and dynamics for protein regulation and drug design.
Academic Article Energetic and conformational contributions to the stability of Okazaki fragments.
Academic Article Antimetabolite incorporation into DNA: structural and thermodynamic basis for anticancer activity.
Academic Article NMR structure of the 3' stem-loop from human U4 snRNA.
Academic Article Structural basis for topoisomerase I inhibition by nucleoside analogs.
Academic Article NMR study of the folding-unfolding mechanism for the thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG).
Academic Article A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Academic Article The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs.
Academic Article Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.
Academic Article Prospective utility of cerebral proton magnetic resonance spectroscopy in monitoring HIV infection and its associated neurological impairment.
Academic Article Quantum mechanical calculations and experimental measurement of N-terminal charge effects on 1HN and 1HC alpha chemical shifts in peptides.
Academic Article Improved 3D gd-HCACO and gd-(H)CACO-TOCSY experiments for isotopically enriched proteins dissolved in H2O.
Academic Article The affinity of an oligodeoxynucleotide-peptide conjugate for an RNA hairpin loop depends on stereochemistry at the DNA-peptide junction.
Academic Article A 3D NOESY-(HCACO)NH experiment for the measurement of NOEs involving 1H alpha in 13C/15N-labeled proteins dissolved in H2O.
Academic Article Sequential assignment and secondary structure determination for the Src homology 2 domain of hematopoietic cellular kinase.
Academic Article Solution structures of 5-fluorouracil-substituted RNA duplexes containing G-U wobble base pairs.
Academic Article Cytarabine-induced destabilization of a model Okazaki fragment.
Academic Article Self-association and backbone dynamics of the hck SH2 domain in the free and phosphopeptide-complexed forms.
Academic Article Comparison of SH3 and SH2 domain dynamics when expressed alone or in an SH(3+2) construct: the role of protein dynamics in functional regulation.
Academic Article Hydrogen exchange shows peptide binding stabilizes motions in Hck SH2.
Academic Article Polarity of annealing and structural analysis of the RNase H resistant alpha-5'-d[TACACA].beta-5'-r[AUGUGU] hybrid determined by high-field 1H, 13C, and 31P NMR analysis.
Academic Article Cytarabine-induced destabilization and bending of a model Okazaki fragment.
Academic Article Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP.
Academic Article Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
Academic Article Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
Academic Article Binding of ethidium to DNA measured using a 2D diffusion-modulated gradient COSY NMR experiment.
Academic Article Dynamics of the Hck-SH3 domain: comparison of experiment with multiple molecular dynamics simulations.
Academic Article Antineoplastic activity of a novel multimeric gemcitabine-monophosphate prodrug against thyroid cancer cells in vitro.
Concept Oxidative Stress
Concept Thymidylate Synthase
Concept Drug Screening Assays, Antitumor
Concept Calorimetry, Differential Scanning
Concept Reactive Oxygen Species
Concept Protein Structure, Tertiary
Concept Solubility
Concept Antigens, Surface
Concept Genome, Human
Concept Binding Sites
Concept Stearic Acids
Concept Feasibility Studies
Concept Computer Simulation
Concept Strontium
Concept Molecular Dynamics Simulation
Concept Amino Acid Sequence
Concept Drug Delivery Systems
Concept Stress, Physiological
Concept Spectrophotometry, Ultraviolet
Concept Signal Processing, Computer-Assisted
Concept Ribonucleoprotein, U2 Small Nuclear
Concept Ribonucleoprotein, U4-U6 Small Nuclear
Concept snRNP Core Proteins
Concept DNA Breaks, Single-Stranded
Concept Static Electricity
Concept Molecular Structure
Concept Conserved Sequence
Concept Complement System Proteins
Concept Sequence Deletion
Concept Ribonucleoproteins, Small Nuclear
Concept Drug Synergism
Concept Signal Transduction
Concept Protein Structure, Secondary
Concept Gene Expression Profiling
Concept src Homology Domains
Concept Drug Stability
Concept RNA, Small Nuclear
Concept RNA, Small Interfering
Concept Mass Spectrometry
Concept Magnetic Resonance Spectroscopy
Concept Uracil
Concept Safety
Concept Uridine
Concept Urinary Bladder Neoplasms
Concept Cell Survival
Concept Receptors, Cell Surface
Concept DNA Breaks, Double-Stranded
Concept Spectrometry, Fluorescence
Concept Macromolecular Substances
Concept Ribonucleoprotein, U1 Small Nuclear
Concept Prospective Studies
Concept Sequence Homology, Amino Acid
Concept Solutions
Concept Simian virus 40
Concept Substrate Specificity
Concept RNA Splicing
Concept Serine Endopeptidases
Concept Oligonucleotide Array Sequence Analysis
Concept United States
Concept Structure-Activity Relationship
Concept National Cancer Institute (U.S.)
Concept Base Sequence
Concept Genome, Viral
Concept DNA, Single-Stranded
Concept Molecular Sequence Data
Concept RNA, Double-Stranded
Academic Article Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity.
Academic Article Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages.
Academic Article TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.
Academic Article Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity.
Academic Article Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.
Academic Article Site-specific DNA-doxorubicin conjugates display enhanced cytotoxicity to breast cancer cells.
Academic Article The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells.
Academic Article The cytotoxic and pro-apoptotic activities of the novel fluoropyrimidine F10 towards prostate cancer cells are enhanced by Zn(2+) -chelation and inhibiting the serine protease Omi/HtrA2.
Academic Article Thymineless death in F10-treated AML cells occurs via lipid raft depletion and Fas/FasL co-localization in the plasma membrane with activation of the extrinsic apoptotic pathway.
Academic Article Importance of long-time simulations for rare event sampling in zinc finger proteins.
Academic Article Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells.
Academic Article The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence.
Academic Article F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.
Academic Article All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10.
Academic Article Selection of a Novel Aptamer Against Vitronectin Using Capillary Electrophoresis and Next Generation Sequencing.
Academic Article Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-?B Essential Modulator).
Academic Article F10 Inhibits Growth of PC3 Xenografts and Enhances the Effects of Radiation Therapy.
Academic Article The Lown Symposium: The Field of DNA Minor Groove Binders Celebrates the Career of Professor J. William Lown.
Grant IMPACT OF 5-FU ON THE STRUCTURE OF THE U4-U6 COMPLEX
Grant IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX
Grant DNA-DIRECTED EFFECTS OF FdUMP(N)
Academic Article All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic.
Academic Article All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer.
Academic Article All-atom molecular dynamics comparison of disease-associated zinc fingers.
Academic Article Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides.
Grant Development of a CF10 Predictive Gene Signature in CRC Organoids.
Grant Aptamer-Based Radiopharmaceuticals for the Targeted Alpha Particle Therapy of Prostate Cancer
Academic Article Secondary Structure-Dependent Physicochemical Interaction of Oligonucleotides with Gold Nanorod and Photothermal Effect for Future Applications: A New Insight.
Academic Article Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition.
Academic Article Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug Screening.
Academic Article Dysregulated Pyrimidine Biosynthesis Contributes to 5-FU Resistance in SCLC Patient-Derived Organoids but Response to a Novel Polymeric Fluoropyrimidine, CF10.
Academic Article Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.
Search Criteria
  • National Cancer Institute
  • U
  • S